Pyrafat
Brand names,
Pyrafat
Analogs
Pyrafat
Brand Names Mixture
Pyrafat
Chemical_Formula
C43H51N3O11
Pyrafat
RX_link
http://www.rxlist.com/cgi/generic/xifaxan.htm
Pyrafat
fda sheet
Pyrafat
msds (material safety sheet)
Pyrafat
Synthesis Reference
No information avaliable
Pyrafat
Molecular Weight
785.879 g/mol
Pyrafat
Melting Point
No information avaliable
Pyrafat
H2O Solubility
No information avaliable
Pyrafat
State
No information avaliable
Pyrafat
LogP
4.161
Pyrafat
Dosage Forms
No information avaliable
Pyrafat
Indication
For the treatment of patients (>=12 years of age) with travelers' diarrhea caused by noninvasive strains of Escherichia coli.
Pyrafat
Pharmacology
Rifaximin is a structural analog of rifampin and non-systemic, gastrointestinal site-specific antibiotic. Rifaximin acts by inhibiting bacterial ribonucleic acid (RNA) synthesis. While an increase in pulmonary hydrogen excretion is evident in diverticular disease, the therapeutic effect of rifaximin does not appear to be due to a persistent correction of this alteration and the drug appears to cause no significant imbalance in the intestinal ecosystem.
Pyrafat
Absorption
Low absorption in both the fasting state and when administered within 30 minutes of a high-fat breakfast.
Pyrafat
side effects and Toxicity
LD50 > 2 g/kg (orally, in rats)
Pyrafat
Patient Information
No information avaliable
Pyrafat
Organisms Affected
Enteric bacteria and eubacteria