Pyrazinamdie
Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C43H51N3O11
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RX_link
http://www.rxlist.com/cgi/generic/xifaxan.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
785.879 g/mol
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Melting Point
No information avaliable
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H2O Solubility
No information avaliable
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State
No information avaliable
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LogP
4.161
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Dosage Forms
No information avaliable
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Indication
For the treatment of patients (>=12 years of age) with travelers' diarrhea caused by noninvasive strains of Escherichia coli.
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Pharmacology
Rifaximin is a structural analog of rifampin and non-systemic, gastrointestinal site-specific antibiotic. Rifaximin acts by inhibiting bacterial ribonucleic acid (RNA) synthesis. While an increase in pulmonary hydrogen excretion is evident in diverticular disease, the therapeutic effect of rifaximin does not appear to be due to a persistent correction of this alteration and the drug appears to cause no significant imbalance in the intestinal ecosystem.
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Absorption
Low absorption in both the fasting state and when administered within 30 minutes of a high-fat breakfast.
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side effects and Toxicity
LD50 > 2 g/kg (orally, in rats)
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Patient Information
No information avaliable
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Organisms Affected
Enteric bacteria and eubacteria