Pyrazinecarboxylic acid amide
Brand names,
Pyrazinecarboxylic acid amide
Analogs
Pyrazinecarboxylic acid amide
Brand Names Mixture
Pyrazinecarboxylic acid amide
Chemical_Formula
C43H51N3O11
Pyrazinecarboxylic acid amide
RX_link
http://www.rxlist.com/cgi/generic/xifaxan.htm
Pyrazinecarboxylic acid amide
fda sheet
Pyrazinecarboxylic acid amide
msds (material safety sheet)
Pyrazinecarboxylic acid amide
Synthesis Reference
No information avaliable
Pyrazinecarboxylic acid amide
Molecular Weight
785.879 g/mol
Pyrazinecarboxylic acid amide
Melting Point
No information avaliable
Pyrazinecarboxylic acid amide
H2O Solubility
No information avaliable
Pyrazinecarboxylic acid amide
State
No information avaliable
Pyrazinecarboxylic acid amide
LogP
4.161
Pyrazinecarboxylic acid amide
Dosage Forms
No information avaliable
Pyrazinecarboxylic acid amide
Indication
For the treatment of patients (>=12 years of age) with travelers' diarrhea caused by noninvasive strains of Escherichia coli.
Pyrazinecarboxylic acid amide
Pharmacology
Rifaximin is a structural analog of rifampin and non-systemic, gastrointestinal site-specific antibiotic. Rifaximin acts by inhibiting bacterial ribonucleic acid (RNA) synthesis. While an increase in pulmonary hydrogen excretion is evident in diverticular disease, the therapeutic effect of rifaximin does not appear to be due to a persistent correction of this alteration and the drug appears to cause no significant imbalance in the intestinal ecosystem.
Pyrazinecarboxylic acid amide
Absorption
Low absorption in both the fasting state and when administered within 30 minutes of a high-fat breakfast.
Pyrazinecarboxylic acid amide
side effects and Toxicity
LD50 > 2 g/kg (orally, in rats)
Pyrazinecarboxylic acid amide
Patient Information
No information avaliable
Pyrazinecarboxylic acid amide
Organisms Affected
Enteric bacteria and eubacteria