Dipimide
Brand names,
Dipimide
Analogs
Dipimide
Brand Names Mixture
Dipimide
Chemical_Formula
C43H51N3O11
Dipimide
RX_link
http://www.rxlist.com/cgi/generic/xifaxan.htm
Dipimide
fda sheet
Dipimide
msds (material safety sheet)
Dipimide
Synthesis Reference
No information avaliable
Dipimide
Molecular Weight
785.879 g/mol
Dipimide
Melting Point
No information avaliable
Dipimide
H2O Solubility
No information avaliable
Dipimide
State
No information avaliable
Dipimide
LogP
4.161
Dipimide
Dosage Forms
No information avaliable
Dipimide
Indication
For the treatment of patients (>=12 years of age) with travelers' diarrhea caused by noninvasive strains of Escherichia coli.
Dipimide
Pharmacology
Rifaximin is a structural analog of rifampin and non-systemic, gastrointestinal site-specific antibiotic. Rifaximin acts by inhibiting bacterial ribonucleic acid (RNA) synthesis. While an increase in pulmonary hydrogen excretion is evident in diverticular disease, the therapeutic effect of rifaximin does not appear to be due to a persistent correction of this alteration and the drug appears to cause no significant imbalance in the intestinal ecosystem.
Dipimide
Absorption
Low absorption in both the fasting state and when administered within 30 minutes of a high-fat breakfast.
Dipimide
side effects and Toxicity
LD50 > 2 g/kg (orally, in rats)
Dipimide
Patient Information
No information avaliable
Dipimide
Organisms Affected
Enteric bacteria and eubacteria