Pyrazine carboxylamide
Brand names,
Pyrazine carboxylamide
Analogs
Pyrazine carboxylamide
Brand Names Mixture
Pyrazine carboxylamide
Chemical_Formula
C43H51N3O11
Pyrazine carboxylamide
RX_link
http://www.rxlist.com/cgi/generic/xifaxan.htm
Pyrazine carboxylamide
fda sheet
Pyrazine carboxylamide
msds (material safety sheet)
Pyrazine carboxylamide
Synthesis Reference
No information avaliable
Pyrazine carboxylamide
Molecular Weight
785.879 g/mol
Pyrazine carboxylamide
Melting Point
No information avaliable
Pyrazine carboxylamide
H2O Solubility
No information avaliable
Pyrazine carboxylamide
State
No information avaliable
Pyrazine carboxylamide
LogP
4.161
Pyrazine carboxylamide
Dosage Forms
No information avaliable
Pyrazine carboxylamide
Indication
For the treatment of patients (>=12 years of age) with travelers' diarrhea caused by noninvasive strains of Escherichia coli.
Pyrazine carboxylamide
Pharmacology
Rifaximin is a structural analog of rifampin and non-systemic, gastrointestinal site-specific antibiotic. Rifaximin acts by inhibiting bacterial ribonucleic acid (RNA) synthesis. While an increase in pulmonary hydrogen excretion is evident in diverticular disease, the therapeutic effect of rifaximin does not appear to be due to a persistent correction of this alteration and the drug appears to cause no significant imbalance in the intestinal ecosystem.
Pyrazine carboxylamide
Absorption
Low absorption in both the fasting state and when administered within 30 minutes of a high-fat breakfast.
Pyrazine carboxylamide
side effects and Toxicity
LD50 > 2 g/kg (orally, in rats)
Pyrazine carboxylamide
Patient Information
No information avaliable
Pyrazine carboxylamide
Organisms Affected
Enteric bacteria and eubacteria