Proma
Brand names,
Proma
Analogs
Proma
Brand Names Mixture
- Depo-Medrol with Lidocaine (Lidocaine Hydrochloride + Methylprednisolone Acetate)
- Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Sulfur)
- Methylprednisolone Sodium Succinate for Injection (Methylprednisolone + Water)
- Neo-Medrol (Methylprednisolone Acetate + Neomycin Sulfate)
- Neo-Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Neomycin Sulfate + Sulfur)
Proma
Chemical_Formula
C22H30O5
Proma
RX_link
http://www.rxlist.com/cgi/generic/methprd.htm
Proma
fda sheet
Proma
msds (material safety sheet)
Proma
Synthesis Reference
Sebek, Spero, U.S. Pat. 2,897,218 (1959)
Proma
Molecular Weight
374.471 g/mol
Proma
Melting Point
232.5 oC
Proma
H2O Solubility
120 mg/L
Proma
State
Solid
Proma
LogP
2.134
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Dosage Forms
Tablets; Suspension
Proma
Indication
Adjunctive therapy for short-term administration in rheumatoid arthritis.
Proma
Pharmacology
Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.
Proma
Absorption
Oral bioavailability 80-99%
Proma
side effects and Toxicity
LD50=2000 mg/kg (orally in rat)
Proma
Patient Information
Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or
measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.
Proma
Organisms Affected
Humans and other mammals