Pre-Op
Brand names,
Pre-Op
Analogs
Pre-Op
Brand Names Mixture
- Fosteen Dermatologic Shampoo (Hexachlorophene + Lanolin + Salicylic Acid + Sulfur)
- Hexaphenyl (Hexachlorophene + Isopropyl Alcohol)
Pre-Op
Chemical_Formula
C13H6Cl6O2
Pre-Op
RX_link
http://www.rxlist.com/cgi/generic2/hexchlorph.htm
Pre-Op
fda sheet
Pre-Op
msds (material safety sheet)
Pre-Op
Synthesis Reference
No information avaliable
Pre-Op
Molecular Weight
406.902 g/mol
Pre-Op
Melting Point
166.5 oC (boiling point)
Pre-Op
H2O Solubility
140 mg/L
Pre-Op
State
Liquid
Pre-Op
LogP
6.941
Pre-Op
Dosage Forms
Liquid
Pre-Op
Indication
For use as a surgical scrub and a bacteriostatic skin cleanser. It may also be used to control an outbreak of gram-positive infection where other infection control procedures have been unsuccessful.
Pre-Op
Pharmacology
Hexachlorophene, a detergent cleanser, is an antibacterial sudsing emulsion for topical administration. It is a bacteriostatic cleansing agent. It cleanses the skin thoroughly and has bacteriostatic action against staphylococci and other gram-positive bacteria. Cumulative antibacterial action develops with repeated use. Cleansing with alcohol or soaps containing alcohol removes the antibacterial residue.
Pre-Op
Absorption
Detectable blood levels of hexachlorophene following absorption through intact skin have been found in subjects who regularly scrubbed with hexachlorophene.
Pre-Op
side effects and Toxicity
Oral, rat LD50: 66 mg/kg. Signs of overdose include anorexia, vomiting, abdominal cramps, diarrhea, dehydration, convulsions, hypotension, and shock, and in several reported instances, fatalities.
Pre-Op
Patient Information
No information avaliable
Pre-Op
Organisms Affected
Enteric bacteria and other eubacteria