Phisodan
Brand names,
Phisodan
Analogs
Phisodan
Brand Names Mixture
- Fosteen Dermatologic Shampoo (Hexachlorophene + Lanolin + Salicylic Acid + Sulfur)
- Hexaphenyl (Hexachlorophene + Isopropyl Alcohol)
Phisodan
Chemical_Formula
C13H6Cl6O2
Phisodan
RX_link
http://www.rxlist.com/cgi/generic2/hexchlorph.htm
Phisodan
fda sheet
Phisodan
msds (material safety sheet)
Phisodan
Synthesis Reference
No information avaliable
Phisodan
Molecular Weight
406.902 g/mol
Phisodan
Melting Point
166.5 oC (boiling point)
Phisodan
H2O Solubility
140 mg/L
Phisodan
State
Liquid
Phisodan
LogP
6.941
Phisodan
Dosage Forms
Liquid
Phisodan
Indication
For use as a surgical scrub and a bacteriostatic skin cleanser. It may also be used to control an outbreak of gram-positive infection where other infection control procedures have been unsuccessful.
Phisodan
Pharmacology
Hexachlorophene, a detergent cleanser, is an antibacterial sudsing emulsion for topical administration. It is a bacteriostatic cleansing agent. It cleanses the skin thoroughly and has bacteriostatic action against staphylococci and other gram-positive bacteria. Cumulative antibacterial action develops with repeated use. Cleansing with alcohol or soaps containing alcohol removes the antibacterial residue.
Phisodan
Absorption
Detectable blood levels of hexachlorophene following absorption through intact skin have been found in subjects who regularly scrubbed with hexachlorophene.
Phisodan
side effects and Toxicity
Oral, rat LD50: 66 mg/kg. Signs of overdose include anorexia, vomiting, abdominal cramps, diarrhea, dehydration, convulsions, hypotension, and shock, and in several reported instances, fatalities.
Phisodan
Patient Information
No information avaliable
Phisodan
Organisms Affected
Enteric bacteria and other eubacteria