Phisohex
Brand names,
Phisohex
Analogs
Phisohex
Brand Names Mixture
- Fosteen Dermatologic Shampoo (Hexachlorophene + Lanolin + Salicylic Acid + Sulfur)
- Hexaphenyl (Hexachlorophene + Isopropyl Alcohol)
Phisohex
Chemical_Formula
C13H6Cl6O2
Phisohex
RX_link
http://www.rxlist.com/cgi/generic2/hexchlorph.htm
Phisohex
fda sheet
Phisohex
msds (material safety sheet)
Phisohex
Synthesis Reference
No information avaliable
Phisohex
Molecular Weight
406.902 g/mol
Phisohex
Melting Point
166.5 oC (boiling point)
Phisohex
H2O Solubility
140 mg/L
Phisohex
State
Liquid
Phisohex
LogP
6.941
Phisohex
Dosage Forms
Liquid
Phisohex
Indication
For use as a surgical scrub and a bacteriostatic skin cleanser. It may also be used to control an outbreak of gram-positive infection where other infection control procedures have been unsuccessful.
Phisohex
Pharmacology
Hexachlorophene, a detergent cleanser, is an antibacterial sudsing emulsion for topical administration. It is a bacteriostatic cleansing agent. It cleanses the skin thoroughly and has bacteriostatic action against staphylococci and other gram-positive bacteria. Cumulative antibacterial action develops with repeated use. Cleansing with alcohol or soaps containing alcohol removes the antibacterial residue.
Phisohex
Absorption
Detectable blood levels of hexachlorophene following absorption through intact skin have been found in subjects who regularly scrubbed with hexachlorophene.
Phisohex
side effects and Toxicity
Oral, rat LD50: 66 mg/kg. Signs of overdose include anorexia, vomiting, abdominal cramps, diarrhea, dehydration, convulsions, hypotension, and shock, and in several reported instances, fatalities.
Phisohex
Patient Information
No information avaliable
Phisohex
Organisms Affected
Enteric bacteria and other eubacteria