Cotofilm
Brand names,
Cotofilm
Analogs
Cotofilm
Brand Names Mixture
- Fosteen Dermatologic Shampoo (Hexachlorophene + Lanolin + Salicylic Acid + Sulfur)
- Hexaphenyl (Hexachlorophene + Isopropyl Alcohol)
Cotofilm
Chemical_Formula
C13H6Cl6O2
Cotofilm
RX_link
http://www.rxlist.com/cgi/generic2/hexchlorph.htm
Cotofilm
fda sheet
Cotofilm
msds (material safety sheet)
Cotofilm
Synthesis Reference
No information avaliable
Cotofilm
Molecular Weight
406.902 g/mol
Cotofilm
Melting Point
166.5 oC (boiling point)
Cotofilm
H2O Solubility
140 mg/L
Cotofilm
State
Liquid
Cotofilm
LogP
6.941
Cotofilm
Dosage Forms
Liquid
Cotofilm
Indication
For use as a surgical scrub and a bacteriostatic skin cleanser. It may also be used to control an outbreak of gram-positive infection where other infection control procedures have been unsuccessful.
Cotofilm
Pharmacology
Hexachlorophene, a detergent cleanser, is an antibacterial sudsing emulsion for topical administration. It is a bacteriostatic cleansing agent. It cleanses the skin thoroughly and has bacteriostatic action against staphylococci and other gram-positive bacteria. Cumulative antibacterial action develops with repeated use. Cleansing with alcohol or soaps containing alcohol removes the antibacterial residue.
Cotofilm
Absorption
Detectable blood levels of hexachlorophene following absorption through intact skin have been found in subjects who regularly scrubbed with hexachlorophene.
Cotofilm
side effects and Toxicity
Oral, rat LD50: 66 mg/kg. Signs of overdose include anorexia, vomiting, abdominal cramps, diarrhea, dehydration, convulsions, hypotension, and shock, and in several reported instances, fatalities.
Cotofilm
Patient Information
No information avaliable
Cotofilm
Organisms Affected
Enteric bacteria and other eubacteria