Esametone
Material Safety Data Sheet
6-alpha-Methylprednisolone, 99%
ACC# 01458
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Section 1 - Chemical Product and Company Identification |
MSDS Name: 6-alpha-Methylprednisolone, 99%
Catalog Numbers:
AC338800000, AC338801000, AC338805000
Synonyms:
Medrol
Company Identification:
Acros Organics N.V.
One Reagent Lane
Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300
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Section 2 - Composition, Information on Ingredients
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| CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
| 83-43-2 |
6-alpha-Methylprednisolone |
99% | 201-476-4 |
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Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Not available.
Target Organs: Eyes, immune system.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
Harmful if absorbed through the skin.
Ingestion:
Harmful if swallowed.
Inhalation:
Harmful if inhaled. May cause irritation of the respiratory tract
with burning pain in the nose and throat, coughing, wheezing,
shortness of breath and pulmonary edema.
Chronic:
Not available.
Prolonged or repeated contact with concentrated solutions causes
tissue damage. "Soda ulcers" on the hands and perforation of the
nasal septum have
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Section 4 - First Aid Measures
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Eyes:
Flush eyes with plenty of water for at least 15 minutes, occasionally
lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
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Section 5 - Fire Fighting Measures
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General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear.
Extinguishing Media:
Use foam, dry chemical, or carbon dioxide.
Flash Point: Not available.
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
Not published.
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Section 6 - Accidental Release Measures
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General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal
container.
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Section 7 - Handling and Storage
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Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin
and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
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Section 8 - Exposure Controls, Personal Protection
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Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits
| Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
| 6-alpha-Methylprednisolone
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none listed
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none listed
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none listed
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OSHA Vacated PELs:
6-alpha-Methylprednisolone:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Not available.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
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Section 9 - Physical and Chemical Properties
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Physical State: Powder
Appearance: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:227-231 deg C
Decomposition Temperature:Not available.
Solubility: Insoluble.
Specific Gravity/Density:Not available.
Molecular Formula:C22H30O5
Molecular Weight:374.207
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Section 10 - Stability and Reactivity
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Chemical Stability:
Stable.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents, acids, acid chlorides, carbon dioxide, acid
anhydrides.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
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Section 11 - Toxicological Information
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RTECS#:
CAS# 83-43-2:
TU4146000
LD50/LC50:
CAS# 83-43-2:
Oral, rat: LD50 = >4
gm/kg;
.
Carcinogenicity:
CAS# 83-43-2:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
No data available.
Teratogenicity:
No data available.
Reproductive Effects:
No data available.
Mutagenicity:
No data available.
Neurotoxicity:
No data available.
Other Studies:
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Section 12 - Ecological Information
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No information available.
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Section 13 - Disposal Considerations
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Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
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Section 14 - Transport Information
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US DOT |
Canada TDG |
| Shipping Name: |
Not regulated as a hazardous material |
No information available. |
| Hazard Class: |
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| UN Number: |
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| Packing Group: |
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Section 15 - Regulatory Information
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US FEDERAL
TSCA
CAS# 83-43-2 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 83-43-2 is not present on
state lists from CA, PA, MN, MA, FL, or NJ.
California Prop 65
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XN
Risk Phrases:
R 40 Limited evidence of a carcinogenic effect.
Safety Phrases:
S 36/37 Wear suitable protective clothing and gloves.
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
WGK (Water Danger/Protection)
CAS# 83-43-2: No information available.
Canada - DSL/NDSL
CAS# 83-43-2 is listed on Canada's NDSL List.
Canada - WHMIS
WHMIS: Not available.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
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Section 16 - Additional Information
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MSDS Creation Date: 6/17/1999
Revision #3 Date: 10/03/2005
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.