Aminocaproic Acid
Aminocaproic Acid Brand names, Aminocaproic Acid Analogs
Aminocaproic Acid Brand Names Mixture
- No information avaliable
Aminocaproic Acid Chemical_Formula
C6H13NO2
Aminocaproic Acid RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
Aminocaproic Acid fda sheet
Aminocaproic Acid msds (material safety sheet)
Aminocaproic Acid Synthesis Reference
No information avaliable
Aminocaproic Acid Molecular Weight
131.173 g/mol
Aminocaproic Acid Melting Point
205 oC
Aminocaproic Acid H2O Solubility
5.05E+005 mg/L
Aminocaproic Acid State
Solid
Aminocaproic Acid LogP
0.306
Aminocaproic Acid Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
Aminocaproic Acid Indication
For use in the treatment of excessive postoperative bleeding.
Aminocaproic Acid Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Aminocaproic Acid Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Aminocaproic Acid side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Aminocaproic Acid Patient Information
Aminocaproic Acid Organisms Affected
Humans and other mammals
