Pyrimethamine
Pyrimethamine Brand names, Pyrimethamine Analogs
Pyrimethamine Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Pyrimethamine Chemical_Formula
C12H13ClN4
Pyrimethamine RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Pyrimethamine fda sheet
Pyrimethamine msds (material safety sheet)
Pyrimethamine Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Pyrimethamine Molecular Weight
248.711 g/mol
Pyrimethamine Melting Point
233.5 oC
Pyrimethamine H2O Solubility
121 mg/L
Pyrimethamine State
Solid
Pyrimethamine LogP
2.607
Pyrimethamine Dosage Forms
Tablet
Pyrimethamine Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Pyrimethamine Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Pyrimethamine Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Pyrimethamine side effects and Toxicity
No information avaliable
Pyrimethamine Patient Information
Pyrimethamine Organisms Affected
Plasmodium
