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Pyrimethamine Brand names, Pyrimethamine Analogs

Pyrimethamine Brand Names Mixture

  • Fansidar Tablets (Pyrimethamine + Sulfadoxine)
  • Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
  • Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)

Pyrimethamine Chemical_Formula


Pyrimethamine RX_link

Pyrimethamine fda sheet

Pyrimethamine FDA

Pyrimethamine msds (material safety sheet)

Pyrimethamine MSDS

Pyrimethamine Synthesis Reference

Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)

Pyrimethamine Molecular Weight

248.711 g/mol

Pyrimethamine Melting Point

233.5 oC

Pyrimethamine H2O Solubility

121 mg/L

Pyrimethamine State


Pyrimethamine LogP


Pyrimethamine Dosage Forms


Pyrimethamine Indication

For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine

Pyrimethamine Pharmacology

Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.

Pyrimethamine Absorption

Well absorbed with peak levels occurring between 2 to 6 hours following administration

Pyrimethamine side effects and Toxicity

No information avaliable

Pyrimethamine Patient Information

Pyrimethamine Organisms Affected