Pirimetamina
Pirimetamina Brand names, Pirimetamina Analogs
Pirimetamina Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Pirimetamina Chemical_Formula
C12H13ClN4
Pirimetamina RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Pirimetamina fda sheet
Pirimetamina msds (material safety sheet)
Pirimetamina Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Pirimetamina Molecular Weight
248.711 g/mol
Pirimetamina Melting Point
233.5 oC
Pirimetamina H2O Solubility
121 mg/L
Pirimetamina State
Solid
Pirimetamina LogP
2.607
Pirimetamina Dosage Forms
Tablet
Pirimetamina Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Pirimetamina Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Pirimetamina Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Pirimetamina side effects and Toxicity
No information avaliable
Pirimetamina Patient Information
Pirimetamina Organisms Affected
Plasmodium
