Ethylpyrimidine
Ethylpyrimidine Brand names, Ethylpyrimidine Analogs
Ethylpyrimidine Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Ethylpyrimidine Chemical_Formula
C12H13ClN4
Ethylpyrimidine RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Ethylpyrimidine fda sheet
Ethylpyrimidine msds (material safety sheet)
Ethylpyrimidine Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Ethylpyrimidine Molecular Weight
248.711 g/mol
Ethylpyrimidine Melting Point
233.5 oC
Ethylpyrimidine H2O Solubility
121 mg/L
Ethylpyrimidine State
Solid
Ethylpyrimidine LogP
2.607
Ethylpyrimidine Dosage Forms
Tablet
Ethylpyrimidine Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Ethylpyrimidine Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Ethylpyrimidine Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Ethylpyrimidine side effects and Toxicity
No information avaliable
Ethylpyrimidine Patient Information
Ethylpyrimidine Organisms Affected
Plasmodium
