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Daraprim Brand names, Daraprim Analogs

Daraprim Brand Names Mixture

  • Fansidar Tablets (Pyrimethamine + Sulfadoxine)
  • Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
  • Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)

Daraprim Chemical_Formula


Daraprim RX_link


Daraprim fda sheet

Daraprim FDA

Daraprim msds (material safety sheet)

Daraprim MSDS

Daraprim Synthesis Reference

Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)

Daraprim Molecular Weight

248.711 g/mol

Daraprim Melting Point

233.5 oC

Daraprim H2O Solubility

121 mg/L

Daraprim State


Daraprim LogP


Daraprim Dosage Forms


Daraprim Indication

For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine

Daraprim Pharmacology

Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.

Daraprim Absorption

Well absorbed with peak levels occurring between 2 to 6 hours following administration

Daraprim side effects and Toxicity

No information avaliable

Daraprim Patient Information

Daraprim Organisms Affected