Daraprim
Daraprim Brand names, Daraprim Analogs
Daraprim Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Daraprim Chemical_Formula
C12H13ClN4
Daraprim RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Daraprim fda sheet
Daraprim msds (material safety sheet)
Daraprim Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Daraprim Molecular Weight
248.711 g/mol
Daraprim Melting Point
233.5 oC
Daraprim H2O Solubility
121 mg/L
Daraprim State
Solid
Daraprim LogP
2.607
Daraprim Dosage Forms
Tablet
Daraprim Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Daraprim Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Daraprim Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Daraprim side effects and Toxicity
No information avaliable
Daraprim Patient Information
Daraprim Organisms Affected
Plasmodium
