Darachlor
Darachlor Brand names, Darachlor Analogs
Darachlor Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Darachlor Chemical_Formula
C12H13ClN4
Darachlor RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Darachlor fda sheet
Darachlor msds (material safety sheet)
Darachlor Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Darachlor Molecular Weight
248.711 g/mol
Darachlor Melting Point
233.5 oC
Darachlor H2O Solubility
121 mg/L
Darachlor State
Solid
Darachlor LogP
2.607
Darachlor Dosage Forms
Tablet
Darachlor Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Darachlor Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Darachlor Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Darachlor side effects and Toxicity
No information avaliable
Darachlor Patient Information
Darachlor Organisms Affected
Plasmodium
