Diaminopyritamin
Diaminopyritamin Brand names, Diaminopyritamin Analogs
Diaminopyritamin Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Diaminopyritamin Chemical_Formula
C12H13ClN4
Diaminopyritamin RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Diaminopyritamin fda sheet
Diaminopyritamin msds (material safety sheet)
Diaminopyritamin Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Diaminopyritamin Molecular Weight
248.711 g/mol
Diaminopyritamin Melting Point
233.5 oC
Diaminopyritamin H2O Solubility
121 mg/L
Diaminopyritamin State
Solid
Diaminopyritamin LogP
2.607
Diaminopyritamin Dosage Forms
Tablet
Diaminopyritamin Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Diaminopyritamin Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Diaminopyritamin Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Diaminopyritamin side effects and Toxicity
No information avaliable
Diaminopyritamin Patient Information
Diaminopyritamin Organisms Affected
Plasmodium
