Pirimetamin
Pirimetamin Brand names, Pirimetamin Analogs
Pirimetamin Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Pirimetamin Chemical_Formula
C12H13ClN4
Pirimetamin RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Pirimetamin fda sheet
Pirimetamin msds (material safety sheet)
Pirimetamin Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Pirimetamin Molecular Weight
248.711 g/mol
Pirimetamin Melting Point
233.5 oC
Pirimetamin H2O Solubility
121 mg/L
Pirimetamin State
Solid
Pirimetamin LogP
2.607
Pirimetamin Dosage Forms
Tablet
Pirimetamin Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Pirimetamin Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Pirimetamin Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Pirimetamin side effects and Toxicity
No information avaliable
Pirimetamin Patient Information
Pirimetamin Organisms Affected
Plasmodium
