Pirimetamin

• Antiprotozoals
• Antimalarials
• Folic Acid Antagonists
• ATC:P01BD01

• CD
• Chloridin
• Chloridine
• Chloridyn
• Darachlor
• Daraclor
• Darapram
• Daraprim
• Daraprime
• Diaminopyritamin
• Disulone
• Erbaprelina
• Ethylpyrimidine
• Fansidar
• Khloridin
• Malacid
• Malocid
• Malocide
• Maloprim
• Pirimecidan
• Pirimetamin
• Pirimetamina
• Primethamine
• Pyremethamine
• Pyrimethamin
• Pyrimethamine Hcl
• Tindurin
• Tinduring

• Fansidar Tablets (Pyrimethamine + Sulfadoxine)
• Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
• Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)

C₁₂H₁₃ClN₄

http://www.rxlist.com/cgi/generic2/pyrime.htm

Pirimetamin FDA

Pirimetamin MSDS

Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)

248.711 g/mol

233.5 ^oC

121 mg/L

Solid

2.607

Tablet

For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine

Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.

Well absorbed with peak levels occurring between 2 to 6 hours following administration

No information avaliable

Plasmodium