Malocid
Malocid Brand names, Malocid Analogs
Malocid Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Malocid Chemical_Formula
C12H13ClN4
Malocid RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Malocid fda sheet
Malocid msds (material safety sheet)
Malocid Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Malocid Molecular Weight
248.711 g/mol
Malocid Melting Point
233.5 oC
Malocid H2O Solubility
121 mg/L
Malocid State
Solid
Malocid LogP
2.607
Malocid Dosage Forms
Tablet
Malocid Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Malocid Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Malocid Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Malocid side effects and Toxicity
No information avaliable
Malocid Patient Information
Malocid Organisms Affected
Plasmodium
