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Pyrimethamin Brand names, Pyrimethamin Analogs

Pyrimethamin Brand Names Mixture

  • Fansidar Tablets (Pyrimethamine + Sulfadoxine)
  • Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
  • Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)

Pyrimethamin Chemical_Formula


Pyrimethamin RX_link

Pyrimethamin fda sheet

Pyrimethamin FDA

Pyrimethamin msds (material safety sheet)

Pyrimethamin MSDS

Pyrimethamin Synthesis Reference

Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)

Pyrimethamin Molecular Weight

248.711 g/mol

Pyrimethamin Melting Point

233.5 oC

Pyrimethamin H2O Solubility

121 mg/L

Pyrimethamin State


Pyrimethamin LogP


Pyrimethamin Dosage Forms


Pyrimethamin Indication

For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine

Pyrimethamin Pharmacology

Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.

Pyrimethamin Absorption

Well absorbed with peak levels occurring between 2 to 6 hours following administration

Pyrimethamin side effects and Toxicity

No information avaliable

Pyrimethamin Patient Information

Pyrimethamin Organisms Affected