Pyrimethamin
Pyrimethamin Brand names, Pyrimethamin Analogs
Pyrimethamin Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Pyrimethamin Chemical_Formula
C12H13ClN4
Pyrimethamin RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Pyrimethamin fda sheet
Pyrimethamin msds (material safety sheet)
Pyrimethamin Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Pyrimethamin Molecular Weight
248.711 g/mol
Pyrimethamin Melting Point
233.5 oC
Pyrimethamin H2O Solubility
121 mg/L
Pyrimethamin State
Solid
Pyrimethamin LogP
2.607
Pyrimethamin Dosage Forms
Tablet
Pyrimethamin Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Pyrimethamin Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Pyrimethamin Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Pyrimethamin side effects and Toxicity
No information avaliable
Pyrimethamin Patient Information
Pyrimethamin Organisms Affected
Plasmodium
