Fansidar
Fansidar Brand names, Fansidar Analogs
Fansidar Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Fansidar Chemical_Formula
C12H13ClN4
Fansidar RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Fansidar fda sheet
Fansidar msds (material safety sheet)
Fansidar Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Fansidar Molecular Weight
248.711 g/mol
Fansidar Melting Point
233.5 oC
Fansidar H2O Solubility
121 mg/L
Fansidar State
Solid
Fansidar LogP
2.607
Fansidar Dosage Forms
Tablet
Fansidar Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Fansidar Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Fansidar Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Fansidar side effects and Toxicity
No information avaliable
Fansidar Patient Information
Fansidar Organisms Affected
Plasmodium
