Pyrimethamine Hcl
Pyrimethamine Hcl Brand names, Pyrimethamine Hcl Analogs
Pyrimethamine Hcl Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Pyrimethamine Hcl Chemical_Formula
C12H13ClN4
Pyrimethamine Hcl RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Pyrimethamine Hcl fda sheet
Pyrimethamine Hcl msds (material safety sheet)
Pyrimethamine Hcl Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Pyrimethamine Hcl Molecular Weight
248.711 g/mol
Pyrimethamine Hcl Melting Point
233.5 oC
Pyrimethamine Hcl H2O Solubility
121 mg/L
Pyrimethamine Hcl State
Solid
Pyrimethamine Hcl LogP
2.607
Pyrimethamine Hcl Dosage Forms
Tablet
Pyrimethamine Hcl Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Pyrimethamine Hcl Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Pyrimethamine Hcl Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Pyrimethamine Hcl side effects and Toxicity
No information avaliable
Pyrimethamine Hcl Patient Information
Pyrimethamine Hcl Organisms Affected
Plasmodium
