Pyrimethamine Hcl en es it fr

Pyrimethamine Hcl Brand names, Pyrimethamine Hcl Analogs

Pyrimethamine Hcl Brand Names Mixture

  • Fansidar Tablets (Pyrimethamine + Sulfadoxine)
  • Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
  • Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)

Pyrimethamine Hcl Chemical_Formula


Pyrimethamine Hcl RX_link

Pyrimethamine Hcl fda sheet

Pyrimethamine_Hcl FDA

Pyrimethamine Hcl msds (material safety sheet)

Pyrimethamine_Hcl MSDS

Pyrimethamine Hcl Synthesis Reference

Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)

Pyrimethamine Hcl Molecular Weight

248.711 g/mol

Pyrimethamine Hcl Melting Point

233.5 oC

Pyrimethamine Hcl H2O Solubility

121 mg/L

Pyrimethamine Hcl State


Pyrimethamine Hcl LogP


Pyrimethamine Hcl Dosage Forms


Pyrimethamine Hcl Indication

For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine

Pyrimethamine Hcl Pharmacology

Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.

Pyrimethamine Hcl Absorption

Well absorbed with peak levels occurring between 2 to 6 hours following administration

Pyrimethamine Hcl side effects and Toxicity

No information avaliable

Pyrimethamine Hcl Patient Information

Pyrimethamine Hcl Organisms Affected