Chloridyn
Chloridyn Brand names, Chloridyn Analogs
Chloridyn Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Chloridyn Chemical_Formula
C12H13ClN4
Chloridyn RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Chloridyn fda sheet
Chloridyn msds (material safety sheet)
Chloridyn Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Chloridyn Molecular Weight
248.711 g/mol
Chloridyn Melting Point
233.5 oC
Chloridyn H2O Solubility
121 mg/L
Chloridyn State
Solid
Chloridyn LogP
2.607
Chloridyn Dosage Forms
Tablet
Chloridyn Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Chloridyn Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Chloridyn Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Chloridyn side effects and Toxicity
No information avaliable
Chloridyn Patient Information
Chloridyn Organisms Affected
Plasmodium
