Darapram
Darapram Brand names, Darapram Analogs
Darapram Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Darapram Chemical_Formula
C12H13ClN4
Darapram RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Darapram fda sheet
Darapram msds (material safety sheet)
Darapram Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Darapram Molecular Weight
248.711 g/mol
Darapram Melting Point
233.5 oC
Darapram H2O Solubility
121 mg/L
Darapram State
Solid
Darapram LogP
2.607
Darapram Dosage Forms
Tablet
Darapram Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Darapram Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Darapram Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Darapram side effects and Toxicity
No information avaliable
Darapram Patient Information
Darapram Organisms Affected
Plasmodium
