Primethamine
Primethamine Brand names, Primethamine Analogs
Primethamine Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Primethamine Chemical_Formula
C12H13ClN4
Primethamine RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Primethamine fda sheet
Primethamine msds (material safety sheet)
Primethamine Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Primethamine Molecular Weight
248.711 g/mol
Primethamine Melting Point
233.5 oC
Primethamine H2O Solubility
121 mg/L
Primethamine State
Solid
Primethamine LogP
2.607
Primethamine Dosage Forms
Tablet
Primethamine Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Primethamine Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Primethamine Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Primethamine side effects and Toxicity
No information avaliable
Primethamine Patient Information
Primethamine Organisms Affected
Plasmodium
