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Primethamine Brand names, Primethamine Analogs

Primethamine Brand Names Mixture

  • Fansidar Tablets (Pyrimethamine + Sulfadoxine)
  • Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
  • Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)

Primethamine Chemical_Formula


Primethamine RX_link

Primethamine fda sheet

Primethamine FDA

Primethamine msds (material safety sheet)

Primethamine MSDS

Primethamine Synthesis Reference

Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)

Primethamine Molecular Weight

248.711 g/mol

Primethamine Melting Point

233.5 oC

Primethamine H2O Solubility

121 mg/L

Primethamine State


Primethamine LogP


Primethamine Dosage Forms


Primethamine Indication

For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine

Primethamine Pharmacology

Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.

Primethamine Absorption

Well absorbed with peak levels occurring between 2 to 6 hours following administration

Primethamine side effects and Toxicity

No information avaliable

Primethamine Patient Information

Primethamine Organisms Affected