Pyremethamine
Pyremethamine Brand names, Pyremethamine Analogs
Pyremethamine Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Pyremethamine Chemical_Formula
C12H13ClN4
Pyremethamine RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Pyremethamine fda sheet
Pyremethamine msds (material safety sheet)
Pyremethamine Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Pyremethamine Molecular Weight
248.711 g/mol
Pyremethamine Melting Point
233.5 oC
Pyremethamine H2O Solubility
121 mg/L
Pyremethamine State
Solid
Pyremethamine LogP
2.607
Pyremethamine Dosage Forms
Tablet
Pyremethamine Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Pyremethamine Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Pyremethamine Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Pyremethamine side effects and Toxicity
No information avaliable
Pyremethamine Patient Information
Pyremethamine Organisms Affected
Plasmodium
