Khloridin
Khloridin Brand names, Khloridin Analogs
Khloridin Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Khloridin Chemical_Formula
C12H13ClN4
Khloridin RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Khloridin fda sheet
Khloridin msds (material safety sheet)
Khloridin Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Khloridin Molecular Weight
248.711 g/mol
Khloridin Melting Point
233.5 oC
Khloridin H2O Solubility
121 mg/L
Khloridin State
Solid
Khloridin LogP
2.607
Khloridin Dosage Forms
Tablet
Khloridin Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Khloridin Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Khloridin Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Khloridin side effects and Toxicity
No information avaliable
Khloridin Patient Information
Khloridin Organisms Affected
Plasmodium
