Daraprime
Daraprime Brand names, Daraprime Analogs
Daraprime Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Daraprime Chemical_Formula
C12H13ClN4
Daraprime RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Daraprime fda sheet
Daraprime msds (material safety sheet)
Daraprime Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Daraprime Molecular Weight
248.711 g/mol
Daraprime Melting Point
233.5 oC
Daraprime H2O Solubility
121 mg/L
Daraprime State
Solid
Daraprime LogP
2.607
Daraprime Dosage Forms
Tablet
Daraprime Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Daraprime Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Daraprime Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Daraprime side effects and Toxicity
No information avaliable
Daraprime Patient Information
Daraprime Organisms Affected
Plasmodium
