Daraprime
Brand names,
Daraprime
Analogs
Daraprime
Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Daraprime
Chemical_Formula
C12H13ClN4
Daraprime
RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Daraprime
fda sheet
Daraprime
msds (material safety sheet)
Daraprime
Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Daraprime
Molecular Weight
248.711 g/mol
Daraprime
Melting Point
233.5 oC
Daraprime
H2O Solubility
121 mg/L
Daraprime
State
Solid
Daraprime
LogP
2.607
Daraprime
Dosage Forms
Tablet
Daraprime
Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Daraprime
Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Daraprime
Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Daraprime
side effects and Toxicity
No information avaliable
Daraprime
Patient Information
Daraprime
Organisms Affected
Plasmodium