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Chloridine Brand names, Chloridine Analogs

Chloridine Brand Names Mixture

  • Fansidar Tablets (Pyrimethamine + Sulfadoxine)
  • Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
  • Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)

Chloridine Chemical_Formula


Chloridine RX_link

Chloridine fda sheet

Chloridine FDA

Chloridine msds (material safety sheet)

Chloridine MSDS

Chloridine Synthesis Reference

Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)

Chloridine Molecular Weight

248.711 g/mol

Chloridine Melting Point

233.5 oC

Chloridine H2O Solubility

121 mg/L

Chloridine State


Chloridine LogP


Chloridine Dosage Forms


Chloridine Indication

For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine

Chloridine Pharmacology

Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.

Chloridine Absorption

Well absorbed with peak levels occurring between 2 to 6 hours following administration

Chloridine side effects and Toxicity

No information avaliable

Chloridine Patient Information

Chloridine Organisms Affected