Chloridine
Chloridine Brand names, Chloridine Analogs
Chloridine Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Chloridine Chemical_Formula
C12H13ClN4
Chloridine RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Chloridine fda sheet
Chloridine msds (material safety sheet)
Chloridine Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Chloridine Molecular Weight
248.711 g/mol
Chloridine Melting Point
233.5 oC
Chloridine H2O Solubility
121 mg/L
Chloridine State
Solid
Chloridine LogP
2.607
Chloridine Dosage Forms
Tablet
Chloridine Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Chloridine Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Chloridine Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Chloridine side effects and Toxicity
No information avaliable
Chloridine Patient Information
Chloridine Organisms Affected
Plasmodium
