Erbaprelina
Erbaprelina Brand names, Erbaprelina Analogs
Erbaprelina Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Erbaprelina Chemical_Formula
C12H13ClN4
Erbaprelina RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Erbaprelina fda sheet
Erbaprelina msds (material safety sheet)
Erbaprelina Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Erbaprelina Molecular Weight
248.711 g/mol
Erbaprelina Melting Point
233.5 oC
Erbaprelina H2O Solubility
121 mg/L
Erbaprelina State
Solid
Erbaprelina LogP
2.607
Erbaprelina Dosage Forms
Tablet
Erbaprelina Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Erbaprelina Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Erbaprelina Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Erbaprelina side effects and Toxicity
No information avaliable
Erbaprelina Patient Information
Erbaprelina Organisms Affected
Plasmodium
