Pirimecidan
Pirimecidan Brand names, Pirimecidan Analogs
Pirimecidan Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Pirimecidan Chemical_Formula
C12H13ClN4
Pirimecidan RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Pirimecidan fda sheet
Pirimecidan msds (material safety sheet)
Pirimecidan Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Pirimecidan Molecular Weight
248.711 g/mol
Pirimecidan Melting Point
233.5 oC
Pirimecidan H2O Solubility
121 mg/L
Pirimecidan State
Solid
Pirimecidan LogP
2.607
Pirimecidan Dosage Forms
Tablet
Pirimecidan Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Pirimecidan Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Pirimecidan Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Pirimecidan side effects and Toxicity
No information avaliable
Pirimecidan Patient Information
Pirimecidan Organisms Affected
Plasmodium
