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Pirimecidan Brand names, Pirimecidan Analogs

Pirimecidan Brand Names Mixture

  • Fansidar Tablets (Pyrimethamine + Sulfadoxine)
  • Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
  • Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)

Pirimecidan Chemical_Formula


Pirimecidan RX_link


Pirimecidan fda sheet

Pirimecidan FDA

Pirimecidan msds (material safety sheet)

Pirimecidan MSDS

Pirimecidan Synthesis Reference

Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)

Pirimecidan Molecular Weight

248.711 g/mol

Pirimecidan Melting Point

233.5 oC

Pirimecidan H2O Solubility

121 mg/L

Pirimecidan State


Pirimecidan LogP


Pirimecidan Dosage Forms


Pirimecidan Indication

For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine

Pirimecidan Pharmacology

Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.

Pirimecidan Absorption

Well absorbed with peak levels occurring between 2 to 6 hours following administration

Pirimecidan side effects and Toxicity

No information avaliable

Pirimecidan Patient Information

Pirimecidan Organisms Affected