Daraclor
Daraclor Brand names, Daraclor Analogs
Daraclor Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Daraclor Chemical_Formula
C12H13ClN4
Daraclor RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Daraclor fda sheet
Daraclor msds (material safety sheet)
Daraclor Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Daraclor Molecular Weight
248.711 g/mol
Daraclor Melting Point
233.5 oC
Daraclor H2O Solubility
121 mg/L
Daraclor State
Solid
Daraclor LogP
2.607
Daraclor Dosage Forms
Tablet
Daraclor Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Daraclor Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Daraclor Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Daraclor side effects and Toxicity
No information avaliable
Daraclor Patient Information
Daraclor Organisms Affected
Plasmodium
