Malocide
Malocide Brand names, Malocide Analogs
Malocide Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Malocide Chemical_Formula
C12H13ClN4
Malocide RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Malocide fda sheet
Malocide msds (material safety sheet)
Malocide Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Malocide Molecular Weight
248.711 g/mol
Malocide Melting Point
233.5 oC
Malocide H2O Solubility
121 mg/L
Malocide State
Solid
Malocide LogP
2.607
Malocide Dosage Forms
Tablet
Malocide Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Malocide Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Malocide Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Malocide side effects and Toxicity
No information avaliable
Malocide Patient Information
Malocide Organisms Affected
Plasmodium
