Malacid
Malacid Brand names, Malacid Analogs
Malacid Brand Names Mixture
- Fansidar Tablets (Pyrimethamine + Sulfadoxine)
- Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
- Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)
Malacid Chemical_Formula
C12H13ClN4
Malacid RX_link
http://www.rxlist.com/cgi/generic2/pyrime.htm
Malacid fda sheet
Malacid msds (material safety sheet)
Malacid Synthesis Reference
Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)
Malacid Molecular Weight
248.711 g/mol
Malacid Melting Point
233.5 oC
Malacid H2O Solubility
121 mg/L
Malacid State
Solid
Malacid LogP
2.607
Malacid Dosage Forms
Tablet
Malacid Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Malacid Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.
Malacid Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration
Malacid side effects and Toxicity
No information avaliable
Malacid Patient Information
Malacid Organisms Affected
Plasmodium
