Phtoruracil
Phtoruracil Brand names, Phtoruracil Analogs
Phtoruracil Brand Names Mixture
- No information avaliable
Phtoruracil Chemical_Formula
C4H3FN2O2
Phtoruracil RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Phtoruracil fda sheet
Phtoruracil msds (material safety sheet)
Phtoruracil Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Phtoruracil Molecular Weight
130.077 g/mol
Phtoruracil Melting Point
280-282oC
Phtoruracil H2O Solubility
< 0.1 g/100 mL at 19 °C
Phtoruracil State
Solid
Phtoruracil LogP
-0.77
Phtoruracil Dosage Forms
Topical preparations; Solution for injection
Phtoruracil Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Phtoruracil Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Phtoruracil Absorption
28-100%
Phtoruracil side effects and Toxicity
LD50=230mg/kg (orally in mice)
Phtoruracil Patient Information
Phtoruracil Organisms Affected
Humans and other mammals
