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Phtoruracil Brand names, Phtoruracil Analogs

Phtoruracil Brand Names Mixture

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Phtoruracil Chemical_Formula


Phtoruracil RX_link

Phtoruracil fda sheet

Phtoruracil FDA

Phtoruracil msds (material safety sheet)

Phtoruracil MSDS

Phtoruracil Synthesis Reference

Heidelberger et al., U.S. Pat 2802005(1956)

Phtoruracil Molecular Weight

130.077 g/mol

Phtoruracil Melting Point


Phtoruracil H2O Solubility

< 0.1 g/100 mL at 19 °C

Phtoruracil State


Phtoruracil LogP


Phtoruracil Dosage Forms

Topical preparations; Solution for injection

Phtoruracil Indication

For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.

Phtoruracil Pharmacology

Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.

Phtoruracil Absorption


Phtoruracil side effects and Toxicity

LD50=230mg/kg (orally in mice)

Phtoruracil Patient Information

Phtoruracil Organisms Affected

Humans and other mammals