URF
URF Brand names, URF Analogs
URF Brand Names Mixture
- No information avaliable
URF Chemical_Formula
C4H3FN2O2
URF RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
URF fda sheet
URF msds (material safety sheet)
URF Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
URF Molecular Weight
130.077 g/mol
URF Melting Point
280-282oC
URF H2O Solubility
< 0.1 g/100 mL at 19 °C
URF State
Solid
URF LogP
-0.77
URF Dosage Forms
Topical preparations; Solution for injection
URF Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
URF Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
URF Absorption
28-100%
URF side effects and Toxicity
LD50=230mg/kg (orally in mice)
URF Patient Information
URF Organisms Affected
Humans and other mammals
