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URF Brand names, URF Analogs

URF Brand Names Mixture

  • No information avaliable

URF Chemical_Formula


URF RX_link


URF fda sheet


URF msds (material safety sheet)


URF Synthesis Reference

Heidelberger et al., U.S. Pat 2802005(1956)

URF Molecular Weight

130.077 g/mol

URF Melting Point


URF H2O Solubility

< 0.1 g/100 mL at 19 °C

URF State




URF Dosage Forms

Topical preparations; Solution for injection

URF Indication

For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.

URF Pharmacology

Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.

URF Absorption


URF side effects and Toxicity

LD50=230mg/kg (orally in mice)

URF Patient Information

URF Organisms Affected

Humans and other mammals