Fluri
Fluri Brand names, Fluri Analogs
Fluri Brand Names Mixture
- No information avaliable
Fluri Chemical_Formula
C4H3FN2O2
Fluri RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Fluri fda sheet
Fluri msds (material safety sheet)
Fluri Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Fluri Molecular Weight
130.077 g/mol
Fluri Melting Point
280-282oC
Fluri H2O Solubility
< 0.1 g/100 mL at 19 °C
Fluri State
Solid
Fluri LogP
-0.77
Fluri Dosage Forms
Topical preparations; Solution for injection
Fluri Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Fluri Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Fluri Absorption
28-100%
Fluri side effects and Toxicity
LD50=230mg/kg (orally in mice)
Fluri Patient Information
Fluri Organisms Affected
Humans and other mammals
