Carzonal
Carzonal Brand names, Carzonal Analogs
Carzonal Brand Names Mixture
- No information avaliable
Carzonal Chemical_Formula
C4H3FN2O2
Carzonal RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Carzonal fda sheet
Carzonal msds (material safety sheet)
Carzonal Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Carzonal Molecular Weight
130.077 g/mol
Carzonal Melting Point
280-282oC
Carzonal H2O Solubility
< 0.1 g/100 mL at 19 °C
Carzonal State
Solid
Carzonal LogP
-0.77
Carzonal Dosage Forms
Topical preparations; Solution for injection
Carzonal Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Carzonal Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Carzonal Absorption
28-100%
Carzonal side effects and Toxicity
LD50=230mg/kg (orally in mice)
Carzonal Patient Information
Carzonal Organisms Affected
Humans and other mammals
