Fluracilum
Fluracilum Brand names, Fluracilum Analogs
Fluracilum Brand Names Mixture
- No information avaliable
Fluracilum Chemical_Formula
C4H3FN2O2
Fluracilum RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Fluracilum fda sheet
Fluracilum msds (material safety sheet)
Fluracilum Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Fluracilum Molecular Weight
130.077 g/mol
Fluracilum Melting Point
280-282oC
Fluracilum H2O Solubility
< 0.1 g/100 mL at 19 °C
Fluracilum State
Solid
Fluracilum LogP
-0.77
Fluracilum Dosage Forms
Topical preparations; Solution for injection
Fluracilum Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Fluracilum Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Fluracilum Absorption
28-100%
Fluracilum side effects and Toxicity
LD50=230mg/kg (orally in mice)
Fluracilum Patient Information
Fluracilum Organisms Affected
Humans and other mammals
