Fluro Uracil
Fluro Uracil Brand names, Fluro Uracil Analogs
Fluro Uracil Brand Names Mixture
- No information avaliable
Fluro Uracil Chemical_Formula
C4H3FN2O2
Fluro Uracil RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Fluro Uracil fda sheet
Fluro Uracil msds (material safety sheet)
Fluro Uracil Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Fluro Uracil Molecular Weight
130.077 g/mol
Fluro Uracil Melting Point
280-282oC
Fluro Uracil H2O Solubility
< 0.1 g/100 mL at 19 °C
Fluro Uracil State
Solid
Fluro Uracil LogP
-0.77
Fluro Uracil Dosage Forms
Topical preparations; Solution for injection
Fluro Uracil Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Fluro Uracil Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Fluro Uracil Absorption
28-100%
Fluro Uracil side effects and Toxicity
LD50=230mg/kg (orally in mice)
Fluro Uracil Patient Information
Fluro Uracil Organisms Affected
Humans and other mammals
