Arumel
Arumel Brand names, Arumel Analogs
Arumel Brand Names Mixture
- No information avaliable
Arumel Chemical_Formula
C4H3FN2O2
Arumel RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Arumel fda sheet
Arumel msds (material safety sheet)
Arumel Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Arumel Molecular Weight
130.077 g/mol
Arumel Melting Point
280-282oC
Arumel H2O Solubility
< 0.1 g/100 mL at 19 °C
Arumel State
Solid
Arumel LogP
-0.77
Arumel Dosage Forms
Topical preparations; Solution for injection
Arumel Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Arumel Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Arumel Absorption
28-100%
Arumel side effects and Toxicity
LD50=230mg/kg (orally in mice)
Arumel Patient Information
Arumel Organisms Affected
Humans and other mammals
