Ftoruracil
Ftoruracil Brand names, Ftoruracil Analogs
Ftoruracil Brand Names Mixture
- No information avaliable
Ftoruracil Chemical_Formula
C4H3FN2O2
Ftoruracil RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Ftoruracil fda sheet
Ftoruracil msds (material safety sheet)
Ftoruracil Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Ftoruracil Molecular Weight
130.077 g/mol
Ftoruracil Melting Point
280-282oC
Ftoruracil H2O Solubility
< 0.1 g/100 mL at 19 °C
Ftoruracil State
Solid
Ftoruracil LogP
-0.77
Ftoruracil Dosage Forms
Topical preparations; Solution for injection
Ftoruracil Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Ftoruracil Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Ftoruracil Absorption
28-100%
Ftoruracil side effects and Toxicity
LD50=230mg/kg (orally in mice)
Ftoruracil Patient Information
Ftoruracil Organisms Affected
Humans and other mammals
