Efudix
Efudix Brand names, Efudix Analogs
Efudix Brand Names Mixture
- No information avaliable
Efudix Chemical_Formula
C4H3FN2O2
Efudix RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Efudix fda sheet
Efudix msds (material safety sheet)
Efudix Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Efudix Molecular Weight
130.077 g/mol
Efudix Melting Point
280-282oC
Efudix H2O Solubility
< 0.1 g/100 mL at 19 °C
Efudix State
Solid
Efudix LogP
-0.77
Efudix Dosage Forms
Topical preparations; Solution for injection
Efudix Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Efudix Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Efudix Absorption
28-100%
Efudix side effects and Toxicity
LD50=230mg/kg (orally in mice)
Efudix Patient Information
Efudix Organisms Affected
Humans and other mammals
