Carac
Carac Brand names, Carac Analogs
Carac Brand Names Mixture
- No information avaliable
Carac Chemical_Formula
C4H3FN2O2
Carac RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Carac fda sheet
Carac msds (material safety sheet)
Carac Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Carac Molecular Weight
130.077 g/mol
Carac Melting Point
280-282oC
Carac H2O Solubility
< 0.1 g/100 mL at 19 °C
Carac State
Solid
Carac LogP
-0.77
Carac Dosage Forms
Topical preparations; Solution for injection
Carac Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Carac Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Carac Absorption
28-100%
Carac side effects and Toxicity
LD50=230mg/kg (orally in mice)
Carac Patient Information
Carac Organisms Affected
Humans and other mammals
