Phthoruracil
Phthoruracil Brand names, Phthoruracil Analogs
Phthoruracil Brand Names Mixture
- No information avaliable
Phthoruracil Chemical_Formula
C4H3FN2O2
Phthoruracil RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Phthoruracil fda sheet
Phthoruracil msds (material safety sheet)
Phthoruracil Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Phthoruracil Molecular Weight
130.077 g/mol
Phthoruracil Melting Point
280-282oC
Phthoruracil H2O Solubility
< 0.1 g/100 mL at 19 °C
Phthoruracil State
Solid
Phthoruracil LogP
-0.77
Phthoruracil Dosage Forms
Topical preparations; Solution for injection
Phthoruracil Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Phthoruracil Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Phthoruracil Absorption
28-100%
Phthoruracil side effects and Toxicity
LD50=230mg/kg (orally in mice)
Phthoruracil Patient Information
Phthoruracil Organisms Affected
Humans and other mammals
