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Phthoruracil Brand names, Phthoruracil Analogs

Phthoruracil Brand Names Mixture

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Phthoruracil Chemical_Formula


Phthoruracil RX_link

Phthoruracil fda sheet

Phthoruracil FDA

Phthoruracil msds (material safety sheet)

Phthoruracil MSDS

Phthoruracil Synthesis Reference

Heidelberger et al., U.S. Pat 2802005(1956)

Phthoruracil Molecular Weight

130.077 g/mol

Phthoruracil Melting Point


Phthoruracil H2O Solubility

< 0.1 g/100 mL at 19 °C

Phthoruracil State


Phthoruracil LogP


Phthoruracil Dosage Forms

Topical preparations; Solution for injection

Phthoruracil Indication

For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.

Phthoruracil Pharmacology

Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.

Phthoruracil Absorption


Phthoruracil side effects and Toxicity

LD50=230mg/kg (orally in mice)

Phthoruracil Patient Information

Phthoruracil Organisms Affected

Humans and other mammals