PharmacyCodes



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FU Brand names, FU Analogs

FU Brand Names Mixture

  • No information avaliable

FU Chemical_Formula

C19H21N5O4

FU RX_link

http://www.rxlist.com/cgi/generic3/prazosin.htm

FU fda sheet

FU msds (material safety sheet)

FU MSDS

FU Synthesis Reference

No information avaliable

FU Molecular Weight

383.401 g/mol

FU Melting Point

279 oC

FU H2O Solubility

0.2 mg/mL (as HCl salt)

FU State

Solid

FU LogP

0.934

FU Dosage Forms

Tablet

FU Indication

For treatment of hypertension and chronic heart failure.

FU Pharmacology

Prazosin is an alpha-adrenergic blocking agent used to treat hypertension and benign prostatic hyperplasia. Accordingly, Prazosin is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors. In the human prostate, Prazosin antagonizes phenylephrine (alpha1 agonist)-induced contractions, in vitro, and binds with high affinity to the alpha1c adrenoceptor, which is thought to be the predominant functional type in the prostate. Studies in normal human subjects have shown that Prazosin competitively antagonized the pressor effects of phenylephrine (an alpha1 agonist) and the systolic pressor effect of norepinephrine. The antihypertensive effect of Prazosin results from a decrease in systemic vascular resistance and the parent compound Prazosin is primarily responsible for the antihypertensive activity.

FU Absorption

Well-absorbed from gastrointestinal tract; bioavailability is variable (50 to 85%).

FU side effects and Toxicity

No information avaliable

FU Patient Information

Dizziness or drowsiness may occur after the first dose of this medicine. Avoid driving or performing hazardous tasks for the first 24 hours after taking this medicine or when the dose is increased. Dizziness, light-headedness or fainting may occur, especially when rising from a lying or sitting position. Getting up slowly may help lessen the problem. These effects may also occur if you drink alcohol, stand for long periods of time, exercise, or if the weather is hot. While taking prazosin HCl, be careful in the amount of alcohol you drink. Also, use extra care during exercise or hot weather, or if standing for long periods. Check with your physician if you have any questions.

FU Organisms Affected

Humans and other mammals