5 Fluorouracil en es it fr

5 Fluorouracil Brand names, 5 Fluorouracil Analogs

5 Fluorouracil Brand Names Mixture

  • No information avaliable

5 Fluorouracil Chemical_Formula


5 Fluorouracil RX_link


5 Fluorouracil fda sheet

5_Fluorouracil FDA

5 Fluorouracil msds (material safety sheet)

5_Fluorouracil MSDS

5 Fluorouracil Synthesis Reference

Heidelberger et al., U.S. Pat 2802005(1956)

5 Fluorouracil Molecular Weight

130.077 g/mol

5 Fluorouracil Melting Point


5 Fluorouracil H2O Solubility

< 0.1 g/100 mL at 19 °C

5 Fluorouracil State


5 Fluorouracil LogP


5 Fluorouracil Dosage Forms

Topical preparations; Solution for injection

5 Fluorouracil Indication

For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.

5 Fluorouracil Pharmacology

Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.

5 Fluorouracil Absorption


5 Fluorouracil side effects and Toxicity

LD50=230mg/kg (orally in mice)

5 Fluorouracil Patient Information

5 Fluorouracil Organisms Affected

Humans and other mammals