Fluoroplex
Fluoroplex Brand names, Fluoroplex Analogs
Fluoroplex Brand Names Mixture
- No information avaliable
Fluoroplex Chemical_Formula
C4H3FN2O2
Fluoroplex RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Fluoroplex fda sheet
Fluoroplex msds (material safety sheet)
Fluoroplex Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Fluoroplex Molecular Weight
130.077 g/mol
Fluoroplex Melting Point
280-282oC
Fluoroplex H2O Solubility
< 0.1 g/100 mL at 19 °C
Fluoroplex State
Solid
Fluoroplex LogP
-0.77
Fluoroplex Dosage Forms
Topical preparations; Solution for injection
Fluoroplex Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Fluoroplex Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Fluoroplex Absorption
28-100%
Fluoroplex side effects and Toxicity
LD50=230mg/kg (orally in mice)
Fluoroplex Patient Information
Fluoroplex Organisms Affected
Humans and other mammals
