Adrucil
Adrucil Brand names, Adrucil Analogs
Adrucil Brand Names Mixture
- No information avaliable
Adrucil Chemical_Formula
C4H3FN2O2
Adrucil RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Adrucil fda sheet
Adrucil msds (material safety sheet)
Adrucil Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Adrucil Molecular Weight
130.077 g/mol
Adrucil Melting Point
280-282oC
Adrucil H2O Solubility
< 0.1 g/100 mL at 19 °C
Adrucil State
Solid
Adrucil LogP
-0.77
Adrucil Dosage Forms
Topical preparations; Solution for injection
Adrucil Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Adrucil Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Adrucil Absorption
28-100%
Adrucil side effects and Toxicity
LD50=230mg/kg (orally in mice)
Adrucil Patient Information
Adrucil Organisms Affected
Humans and other mammals
