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Adrucil Brand names, Adrucil Analogs

Adrucil Brand Names Mixture

  • No information avaliable

Adrucil Chemical_Formula


Adrucil RX_link

Adrucil fda sheet

Adrucil FDA

Adrucil msds (material safety sheet)

Adrucil MSDS

Adrucil Synthesis Reference

Heidelberger et al., U.S. Pat 2802005(1956)

Adrucil Molecular Weight

130.077 g/mol

Adrucil Melting Point


Adrucil H2O Solubility

< 0.1 g/100 mL at 19 °C

Adrucil State


Adrucil LogP


Adrucil Dosage Forms

Topical preparations; Solution for injection

Adrucil Indication

For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.

Adrucil Pharmacology

Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.

Adrucil Absorption


Adrucil side effects and Toxicity

LD50=230mg/kg (orally in mice)

Adrucil Patient Information

Adrucil Organisms Affected

Humans and other mammals